Water → Pyrrolo[1,2-b]pyridazin-4(1H)-one

Participants

Reaction Conditions

Reaction Steps

A mixture of ethyl 4-oxo-1,4-dihydropyrrolo[1,2-b]pyridazine-3-carboxylate (206 mg, 1.0 mmol), NaCl (64 mg, 1.1 mmol), water (0.054 mL, 3.0 mmol) and DMSO (2 mL) was heated at 150° C. for 3 hours. At the end of the reaction DMSO was distilled off and the residue was purified by silica gel flash chromatography (eluted with 1-10% EtOAc/CH2Cl2) to give the title compound (90 mg, 67%) as a light yellow solid.

Provenance & Evidence