HuagongsheHuagongshe Chemistry Print Report · For research reference only
1,2,4-Trifluoro-5-nitrobenzene → 4-(2,5-Difluoro-4-nitrophenoxy)-1H-pyrrolo[2,3-b]pyridine
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 1,2,4-Trifluoro-5-nitrobenzene | HCID 75012 | — |
| Reactant | 1H-pyrrolo[2,3-b]pyridin-4-ol | HCID 178516467 | — |
| Product | 4-(2,5-Difluoro-4-nitrophenoxy)-1H-pyrrolo[2,3-b]pyridine | HCID 21081633 | 40% |
Reaction Steps
Following a similar procedure as described in Step A of Example 313 and using 1,2,4-trifluoro-5-nitrobenzene, 1H-pyrrolo[2,3-b]pyridin-4-ol (268 mg, 2.0 mmol) was converted to the title compound (230 mg, 40%). MS(ESI) m/z 292.2 (M+H)+.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07439246B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-07f27674687b41e98cf9740ad9162bc6 |
| Source note | uspto-grants-2008_10 |