HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 4-(trans-beta-Styrenesulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | (E)-2-phenylethene-1-sulfonyl chloride | HCID 5369377 | — |
| Reactant | 4-Hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone | HCID 68493222 | — |
| Solvent | Acetonitrile | HCID 6342 | — |
| Product | 4-(trans-beta-Styrenesulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone | HCID 86628276 | 210.4% |
Reaction Steps
In a similar manner to Step 1 of Example 233, 4-hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0269 g, 0.0583 mmol) was dissolved in acetonitrile (0.650 mL), and the solution was treated with triethylamine (0.0490 mL, 0.350 mmol) and trans-β-styrenesulfonyl chloride (0.0350 g, 0.175 mmol) to obtain 4-(trans-β-styrenesulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0770 g, yield 21%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745641B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-de948f6c0d5e479fa651224261c4a47d |
| Source note | uspto-grants-2010_06 |