HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-Amino-6-chlorobenzaldehyde → (+/-)-(2-Amino-6-chlorophenyl)-(4-fluorophenyl)methanol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-Amino-6-chlorobenzaldehyde | HCID 22399512 | — |
| Reactant | HCID 178418676 | HCID 178418676 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | (+/-)-(2-Amino-6-chlorophenyl)-(4-fluorophenyl)methanol | HCID 69315535 | 57% |
Reaction Steps
This compound was prepared using General Method 1 (EXAMPLE 1) from 2-amino-6-chlorobenzaldehyde (0.30 g, 1.9 mmol) and 4-fluorophenylmagnesium bromide (1 M in THF, 3.8 mL) to afford 0.28 g (57%) of (±)-(2-amino-6-chlorophenyl)-(4-fluorophenyl)methanol after flash chromatography (4:1 hexanes:ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07442696B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-ab9d8f78d16f40d3a2cbdea772ddc349 |
| Source note | uspto-grants-2008_10 |