Ethyl Acetate → (+/-)-5-chloro-4-(4-fluorophenyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one

Participants

Role	Name	HCID	Charge
Reactant	Ethyl Acetate	HCID 8857	—
Reactant	(+/-)-(2-Amino-6-chlorophenyl)-(4-fluorophenyl)methanol	HCID 69315535	—
Product	(+/-)-5-chloro-4-(4-fluorophenyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one	HCID 69317854	45%

Reaction Steps

This compound was prepared using General Method 2 (EXAMPLE 1) from (±)-1-(2-amino-6-chlorophenyl)-(4-fluorophenyl)methanol (0.28 g, 1.1 mmol) to afford 0.14 g (45%) of (±)-5-chloro-4-(4-fluorophenyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one after flash chromatography (4:1 hexanes:ethyl acetate).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07442696B2
Source dataset	uspto-grants-2008_10
ORD ID	ord-dd2961dc935d4cfc9f927a65e25b5586
Source note	uspto-grants-2008_10