HuagongsheHuagongshe Chemistry Print Report · For research reference only
Ethyl Acetate → (+/-)-5-chloro-4-(3,4-difluorobenzyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Ethyl Acetate | HCID 8857 | — |
| Reactant | (+/-)-1-(2-Amino-6-chlorophenyl)-2-(3,4-difluorophenyl)ethanol | HCID 69318113 | — |
| Product | (+/-)-5-chloro-4-(3,4-difluorobenzyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one | HCID 69315430 | 64% |
Reaction Steps
This compound was prepared using General Method 2 (EXAMPLE 1) from (±)-1-(2-amino-6-chlorophenyl)-2-(3,4-difluorophenyl)ethanol (0.28 g, 1.1 mmol) to afford 0.21 g (64%) of (±)-5-chloro-4-(3,4-difluorobenzyl)-1,4-dihydro-2H-3,1-benzoxazin-2-one after flash chromatography (4:1 hexanes:ethyl acetate).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07442696B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-880ff0ba66ce4620b60c7bee49fd0f89 |
| Source note | uspto-grants-2008_10 |