Tetrahydrofuran → HCID 11273779, compound

Participants

Reaction Steps

To a solution of the product from Step 5 (60 mg, 0.12 mmol, 1.00 eq.), triethylamine (33 μL, 0.24 mmol, 2.00 eq.), and anhydrous THF (0.6 mL) is added bromovaleryl chloride (15 μL, 0.11 mmol, 0.95 eq.) under N2 with stirring. The reaction mixture is stirred for 2 hours, then diluted with ethyl acetate, quenched with 1N HCl, and washed with 10% NaHCO3. The organic layer is dried over MgSO4, filtered, and then concentrated in vacuo, yielding product as a white solid (63 mg, 80% crude yield). Calculate mass for C31H43BrFN3O6: 651.23 (mass calculated for Br79 isotope). Mass found for C31H43BrFN3O6: (LCMS) ES+: 676.1 (M+Na), ES− 652.0 (M−1).

Provenance & Evidence