Dimethylformamide → HCID 10116186, compound

Participants

Reaction Steps

To a solution of the product from Step 6 (78 mg, 0.12 mmol, 1.00 eq.) and anhydrous DMF (1 mL) is added Cs2CO3 (flame-dried, 78 mg, 0.24 mmol, 2.00 eq.) under N2 with stirring overnight. The reaction mixture is filtered through Celite and then concentrated in vacuo. The crude product is then stirred with Dowex 50WX2-400 ion-exchange resin at 60° C. for 2 hours. The product is released from resin with 7N NH3/MeOH through a frit and the filtrate is concentrated in vacuo, yielding the final product as a white solid (14 mg, 25% yield). Calculate accurate mass for C26H34BrFN3O4+H1: 472.2611. Accurate Mass found for C26H34BrFN3O4+H1: 472.2592.

Provenance & Evidence