HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloride methanol → 4-Hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloride methanol | HCID 21893726 | — |
| Reactant | 4-(trans-beta-Styrenesulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone | HCID 86628276 | — |
| Product | 4-Hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone | HCID 68493222 | 56.8% |
Reaction Steps
In a similar manner to Step 2 of Example 233, 4-(trans-β-styrenesulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0770 g, 0.0122 mmol) was treated with 10% hydrogen chloride-methanol solution (0.650 mL) to obtain Compound 276 (0.00320 g, yield 49%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07745641B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-fc094dff169440528470cc6234db27fb |
| Source note | uspto-grants-2010_06 |