Methyl iodide → HCID 68711723, compound

HRID 2117371Notes

Reaction equation

HRID 2117371 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:34]=[CH:35][CH:36]=1)[C:6]([NH:8][C:9]1[C:10]([CH3:33])=[C:11]([C:18]([C:20]2[CH:21]=[CH:22][C:23]([N+:30]([O-:32])=[O:31])=[C:24]([CH:29]=2)[C:25]([O:27][CH3:28])=[O:26])=[O:19])[N:12]2[C:17]=1[CH:16]=[CH:15][CH:14]=[CH:13]2)=[O:7].[CH3:37]I>>[CH3:1][O:2][C:3]1[CH:4]=[C:5]([CH:34]=[CH:35][CH:36]=1)[C:6]([N:8]([CH3:37])[C:9]1[C:10]([CH3:33])=[C:11]([C:18]([C:20]2[CH:21]=[CH:22][C:23]([N+:30]([O-:32])=[O:31])=[C:24]([CH:29]=2)[C:25]([O:27][CH3:28])=[O:26])=[O:19])[N:12]2[C:17]=1[CH:16]=[CH:15][CH:14]=[CH:13]2)=[O:7]

Participants

3

Reactant 2

HCID 6328Methyl iodideHCID 68704727HCID 68704727, compound

Product 1

HCID 68711723HCID 68711723, compoundYield 84%

Procedure

This compound is prepared according to the protocol described in the example above by methylating 1.9 g (3.9 mmol) of methyl 5-({1-[(3-methoxybenzoyl)amino]-2-methylindolizin-3-yl}carbonyl)-2-nitrobenzoate with methyl iodide. 1.85 g of a red solid are obtained.

Workup

  1. customThis compound is prepared

Sources & evidence

ORD record
ord-00a6719585274f7b91111079bcf77800
Source dataset
uspto-grants-2008_10
Patent number
US07442708B2

Reaction notes

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