Sodium Hydroxide → HCID 68706657, compound

HRID 2117383Notes

Reaction equation

HRID 2117383 reaction equation
[OH-].[Na+].[CH3:3][O:4][C:5]1[CH:17]=[C:16]([C:18]([C:20]2[N:28]3[C:23]([CH:24]=[CH:25][CH:26]=[CH:27]3)=[C:22]([O:29][CH3:30])[C:21]=2[CH3:31])=[O:19])[CH:15]=[CH:14][C:6]=1[NH:7][CH2:8][C:9]([O:11]CC)=[O:10]>C(O)C>[CH3:3][O:4][C:5]1[CH:17]=[C:16]([C:18]([C:20]2[N:28]3[C:23]([CH:24]=[CH:25][CH:26]=[CH:27]3)=[C:22]([O:29][CH3:30])[C:21]=2[CH3:31])=[O:19])[CH:15]=[CH:14][C:6]=1[NH:7][CH2:8][C:9]([OH:11])=[O:10]

Participants

4

Reactant 2

HCID 14798Sodium HydroxideHCID 68707120HCID 68707120, compound2×

Product 1

HCID 68706657HCID 68706657, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

3.15 ml of 1 N sodium hydroxide are added to 1 g (2.52 mmol) of ethyl 2-{2-methoxy-4-[(1-methoxy-2-methylindolizin-3-yl)carbonyl]anilino}acetate, a compound obtained in Example 195, in solution in 10 ml of ethanol, and the medium is stirred at room temperature overnight. The reaction medium is concentrated under reduced pressure. The residue is taken up in water, washed with ethyl ether and separated after settling out. The aqueous phase is neutralized with 1 N hydrochloric acid. The precipitate formed is filtered off, washed with water, dried and then taken up in ethyl ether, filtered and dried. A yellow powder is obtained.

Workup

  1. concentrationThe reaction medium is concentrated under reduced pressure
  2. washwashed with ethyl ether
  3. customseparated
  4. customThe precipitate formed
  5. filtrationis filtered off
  6. washwashed with water
  7. customdried
  8. filtrationfiltered
  9. customdried
  10. customA yellow powder is obtained

Sources & evidence

ORD record
ord-8f7e1993f8eb42c9a7eedee9194f4e14
Source dataset
uspto-grants-2008_10
Patent number
US07442708B2

Reaction notes

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