Ethyl chloroformate → HCID 68708986, compound

HRID 2117386Notes

Reaction equation

HRID 2117386 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[N:18]3[C:13]([CH:14]=[CH:15][CH:16]=[CH:17]3)=[C:12]([O:19][CH3:20])[C:11]=2[CH3:21])=[O:9])=[CH:4][C:3]=1[O:22][CH3:23].Cl[C:25]([O:27][CH2:28][CH3:29])=[O:26]>>[CH3:23][O:22][C:3]1[CH:4]=[C:5]([C:8]([C:10]2[N:18]3[C:13]([CH:14]=[CH:15][CH:16]=[CH:17]3)=[C:12]([O:19][CH3:20])[C:11]=2[CH3:21])=[O:9])[CH:6]=[CH:7][C:2]=1[NH:1][C:25](=[O:26])[O:27][CH2:28][CH3:29]

Participants

3

Reactant 2

HCID 10928Ethyl chloroformateHCID 11335885HCID 11335885, compound

Product 1

HCID 68708986HCID 68708986, compound

Procedure

This compound was obtained according to the same procedure as that described in Example 199 by acylation of (4-amino-3-methoxyphenyl)(1-methoxy-2-methylindolizin-3-yl)methanone with ethyl chloroformate. The product is purified by flash chromatography on silica, eluting with dichloromethane. A yellow powder is obtained.

Workup

  1. customThis compound was obtained
  2. customThe product is purified by flash chromatography on silica
  3. washeluting with dichloromethane
  4. customA yellow powder is obtained

Sources & evidence

ORD record
ord-746a04f1c83b44d3a355ad4a125b3ea4
Source dataset
uspto-grants-2008_10
Patent number
US07442708B2

Reaction notes

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