Methanesulfonyl chloride → HCID 68712892, compound

HRID 2117387Notes

Reaction equation

HRID 2117387 reaction equation
[NH2:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]([C:10]2[N:18]3[C:13]([CH:14]=[CH:15][CH:16]=[CH:17]3)=[C:12]([O:19][CH3:20])[C:11]=2[CH3:21])=[O:9])=[CH:4][C:3]=1[O:22][CH3:23].[CH3:24][S:25](Cl)(=[O:27])=[O:26]>>[CH3:23][O:22][C:3]1[CH:4]=[C:5]([C:8]([C:10]2[N:18]3[C:13]([CH:14]=[CH:15][CH:16]=[CH:17]3)=[C:12]([O:19][CH3:20])[C:11]=2[CH3:21])=[O:9])[CH:6]=[CH:7][C:2]=1[NH:1][S:25]([CH3:24])(=[O:27])=[O:26]

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 11335885HCID 11335885, compound

Product 1

HCID 68712892HCID 68712892, compound

Procedure

Obtained according to the same procedure as the compound of Example 207, by sulphonylation of (4-amino-3-methoxyphenyl)(1-methoxy-2-methylindolizin-3-yl)methanone with methanesulphonyl chloride. The product is purified by chromatography on a silica column, eluting with a toluene/ethyl acetate (7:3) mixture. A yellow powder is obtained.

Workup

  1. customObtained
  2. customThe product is purified by chromatography on a silica column
  3. washeluting with a toluene/ethyl acetate (7:3) mixture
  4. customA yellow powder is obtained

Sources & evidence

ORD record
ord-4eec98757b444c8a90621e62f7e28ee8
Source dataset
uspto-grants-2008_10
Patent number
US07442708B2

Reaction notes

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