Methanesulfonyl chloride → HCID 68705876, compound

HRID 2117388Notes

Reaction equation

HRID 2117388 reaction equation
[NH2:1][C:2]1[CH:24]=[CH:23][C:5]([C:6]([C:8]2[N:16]3[C:11]([CH:12]=[CH:13][CH:14]=[CH:15]3)=[C:10]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:9]=2[CH3:22])=[O:7])=[CH:4][C:3]=1[O:25][CH3:26].[CH3:27][S:28](Cl)(=[O:30])=[O:29]>>[CH3:26][O:25][C:3]1[CH:4]=[C:5]([CH:23]=[CH:24][C:2]=1[NH:1][S:28]([CH3:27])(=[O:30])=[O:29])[C:6]([C:8]1[N:16]2[C:11]([CH:12]=[CH:13][CH:14]=[CH:15]2)=[C:10]([C:17]([O:19][CH2:20][CH3:21])=[O:18])[C:9]=1[CH3:22])=[O:7]

Participants

3

Reactant 2

HCID 31297Methanesulfonyl chlorideHCID 12069605HCID 12069605, compound

Product 1

HCID 68705876HCID 68705876, compound

Procedure

This compound was obtained according to the same procedure as that described in Example 207, by sulphonylation of ethyl 3-(4-amino-3-methoxybenzoyl)-2-methylindolizin-1-ylcarboxylate, a compound of Example 97, with methanesulphonyl chloride. The product is purified by chromatography on a silica column, eluting with a toluene/ethyl acetate (8:2) mixture. A yellow powder is obtained.

Workup

  1. customThis compound was obtained
  2. customThe product is purified by chromatography on a silica column
  3. washeluting with a toluene/ethyl acetate (8:2) mixture
  4. customA yellow powder is obtained

Sources & evidence

ORD record
ord-bfdddd196dd54edfbacf612b9742655d
Source dataset
uspto-grants-2008_10
Patent number
US07442708B2

Reaction notes

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