HCID 12448337, compound → HCID 178512061, compound

Participants

Reaction Steps

1,4-Dioxaspiro[4.5]dec-6-ylamine (500 mg) was reacted with 2,6-dichloro-phenylcyanamide (595 mg, prepared as described in J. Med. Chem., 1975, 18, 90-99) at 130° C. After 45 minutes, the reaction was stopped and the reaction product was purified by preparative HPLC. The product-containing fractions were combined, the acetonitrile was stripped off in a rotary evaporator, and the aqueous residue was neutralized with potassium carbonate and extracted three times with dichloromethane. Drying over magnesium sulfate was followed by evaporation to dryness. 476 mg of the desired guanidine were obtained.

Provenance & Evidence