2-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride → [5-Methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-(2-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-methanone

HRID 2117401Notes

Reaction equation

HRID 2117401 reaction equation
Cl.[F:2][C:3]([F:15])([F:14])[C:4]1[CH:13]=[CH:12][C:11]2[CH2:10][NH:9][CH2:8][CH2:7][C:6]=2[N:5]=1.[CH3:16][S:17]([C:20]1[CH:21]=[CH:22][C:23]([O:29][C@@H:30]([CH3:35])[C:31]([F:34])([F:33])[F:32])=[C:24]([CH:28]=1)[C:25](O)=[O:26])(=[O:19])=[O:18]>>[CH3:16][S:17]([C:20]1[CH:21]=[CH:22][C:23]([O:29][C@@H:30]([CH3:35])[C:31]([F:32])([F:33])[F:34])=[C:24]([C:25]([N:9]2[CH2:8][CH2:7][C:6]3[N:5]=[C:4]([C:3]([F:2])([F:14])[F:15])[CH:13]=[CH:12][C:11]=3[CH2:10]2)=[O:26])[CH:28]=1)(=[O:19])=[O:18]

Participants

3

Reactant 2

HCID 574452562-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochlorideHCID 58863351(S)-2-(1-Methyl-2,2,2-trifluoroethoxy)-5-methylsulfonylbenzoic acid

Product 1

HCID 58677904[5-Methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-(2-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-methanone

Procedure

Prepared in analogy to example 1.1 from 2-trifluoromethyl-5,6,7,8-tetrahydro-[1,6]naphthyridine hydrochloride (CA [741736-98-1]; WO2004069162) and 5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid (example 2.2).

Sources & evidence

ORD record
ord-ea0ab974eb9c49ed9d607f8e39dc499a
Source dataset
uspto-grants-2008_10
Patent number
US07442710B2

Reaction notes

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