HuagongsheHuagongshe Chemistry Print Report · For research reference only
2-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride → [5-Methanesulfonyl-2-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-(2-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-methanone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | 2-(Trifluoromethyl)-5,6,7,8-tetrahydro-1,6-naphthyridine hydrochloride | HCID 57445256 | — |
| Reactant | 5-Methylsulfonyl-2-[((R)-2,2,2-trifluoro-1-methylethyl)oxy]benzoic acid | HCID 58863354 | — |
| Product | [5-Methanesulfonyl-2-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-phenyl]-(2-trifluoromethyl-7,8-dihydro-5H-[1,6]naphthyridin-6-yl)-methanone | HCID 58677894 | — |
Reaction Steps
Prepared in analogy to example 1.1 from 2-trifluoromethyl-5,6,7,8-tetrahydro-[1,6]naphthyridine hydrochloride (CA [741736-98-1]; WO2004069162) and 5-methanesulfonyl-2-((R)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid (example 2.3).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07442710B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-ebb93ad875054121a05d766418a7f7d4 |
| Source note | uspto-grants-2008_10 |