6-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinoline → HCID 11691743, compound

HRID 2117407Notes

Reaction equation

HRID 2117407 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[CH2:9][NH:8][CH2:7][CH2:6]2.[CH3:15][S:16]([C:19]1[CH:20]=[CH:21][C:22]([O:28][C@@H:29]([CH3:34])[C:30]([F:33])([F:32])[F:31])=[C:23]([CH:27]=1)[C:24](O)=[O:25])(=[O:18])=[O:17]>>[CH3:15][S:16]([C:19]1[CH:20]=[CH:21][C:22]([O:28][C@@H:29]([CH3:34])[C:30]([F:31])([F:32])[F:33])=[C:23]([C:24]([N:8]2[CH2:7][CH2:6][C:5]3[C:10](=[CH:11][CH:12]=[C:3]([C:2]([F:1])([F:13])[F:14])[CH:4]=3)[CH2:9]2)=[O:25])[CH:27]=1)(=[O:18])=[O:17]

Participants

3

Reactant 2

HCID 181765196-(Trifluoromethyl)-1,2,3,4-tetrahydroisoquinolineHCID 58863351(S)-2-(1-Methyl-2,2,2-trifluoroethoxy)-5-methylsulfonylbenzoic acid

Product 1

HCID 11691743HCID 11691743, compound

Procedure

Prepared in analogy to example 1.1 from 6-trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline and 5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid (example 2.2). MS (m/e): 496.0 (M+H+).

Sources & evidence

ORD record
ord-8eb9c7a461834cd59eb8249355050e9b
Source dataset
uspto-grants-2008_10
Patent number
US07442710B2

Reaction notes

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