1,2,3,4-Tetrahydro-8-(trifluoromethyl)isoquinoline → HCID 57445257, compound

HRID 2117409Notes

Reaction equation

HRID 2117409 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][NH:10][CH2:9][CH2:8]2.[CH:15]([O:18][C:19]1[CH:27]=[CH:26][C:25]([S:28]([CH3:31])(=[O:30])=[O:29])=[CH:24][C:20]=1[C:21](O)=[O:22])([CH3:17])[CH3:16]>>[CH:15]([O:18][C:19]1[CH:27]=[CH:26][C:25]([S:28]([CH3:31])(=[O:30])=[O:29])=[CH:24][C:20]=1[C:21]([N:10]1[CH2:9][CH2:8][C:7]2[C:12](=[C:3]([C:2]([F:1])([F:13])[F:14])[CH:4]=[CH:5][CH:6]=2)[CH2:11]1)=[O:22])([CH3:17])[CH3:16]

Participants

3

Reactant 2

HCID 181764921,2,3,4-Tetrahydro-8-(trifluoromethyl)isoquinolineHCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acid

Product 1

HCID 57445257HCID 57445257, compound

Procedure

Prepared in analogy to example 1.1 from 8-trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline and 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example 2.1).

Sources & evidence

ORD record
ord-6da2dd5ae0714fc8b69499841132049b
Source dataset
uspto-grants-2008_10
Patent number
US07442710B2

Reaction notes

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