1,2,3,4-Tetrahydro-8-(trifluoromethyl)isoquinoline → HCID 58677887, compound

HRID 2117410Notes

Reaction equation

HRID 2117410 reaction equation
[F:1][C:2]([F:14])([F:13])[C:3]1[CH:4]=[CH:5][CH:6]=[C:7]2[C:12]=1[CH2:11][NH:10][CH2:9][CH2:8]2.[CH3:15][S:16]([C:19]1[CH:20]=[CH:21][C:22]([O:28][C@@H:29]([CH3:34])[C:30]([F:33])([F:32])[F:31])=[C:23]([CH:27]=1)[C:24](O)=[O:25])(=[O:18])=[O:17]>>[CH3:15][S:16]([C:19]1[CH:20]=[CH:21][C:22]([O:28][C@@H:29]([CH3:34])[C:30]([F:31])([F:32])[F:33])=[C:23]([C:24]([N:10]2[CH2:9][CH2:8][C:7]3[C:12](=[C:3]([C:2]([F:1])([F:13])[F:14])[CH:4]=[CH:5][CH:6]=3)[CH2:11]2)=[O:25])[CH:27]=1)(=[O:18])=[O:17]

Participants

3

Reactant 2

HCID 181764921,2,3,4-Tetrahydro-8-(trifluoromethyl)isoquinolineHCID 58863351(S)-2-(1-Methyl-2,2,2-trifluoroethoxy)-5-methylsulfonylbenzoic acid

Product 1

HCID 58677887HCID 58677887, compound

Procedure

Prepared in analogy to example 1.1 from 8-trifluoromethyl-1,2,3,4-tetrahydro-isoquinoline and 5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid (example 2.2). MS (m/e): MS (m/e): 496.4 (M+H+).

Sources & evidence

ORD record
ord-36e636fe785e4835a032d5c030fc10fa
Source dataset
uspto-grants-2008_10
Patent number
US07442710B2

Reaction notes

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