6-Chloro-1,2,3,4-tetrahydroisoquinoline → HCID 11590739, compound

HRID 2117411Notes

Reaction equation

HRID 2117411 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][NH:7][CH2:6][CH2:5]2.[CH3:12][S:13]([C:16]1[CH:17]=[CH:18][C:19]([O:25][C@@H:26]([CH3:31])[C:27]([F:30])([F:29])[F:28])=[C:20]([CH:24]=1)[C:21](O)=[O:22])(=[O:15])=[O:14]>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][N:7]([C:21]([C:20]1[CH:24]=[C:16]([S:13]([CH3:12])(=[O:14])=[O:15])[CH:17]=[CH:18][C:19]=1[O:25][C@@H:26]([CH3:31])[C:27]([F:29])([F:30])[F:28])=[O:22])[CH2:6][CH2:5]2

Participants

3

Reactant 2

HCID 117895946-Chloro-1,2,3,4-tetrahydroisoquinolineHCID 58863351(S)-2-(1-Methyl-2,2,2-trifluoroethoxy)-5-methylsulfonylbenzoic acid

Product 1

HCID 11590739HCID 11590739, compound

Procedure

Prepared in analogy to example 1.1 from 6-chloro-1,2,3,4-tetrahydro-isoquinoline (CA [33537-99-4]) and 5-methanesulfonyl-2-((S)-2,2,2-trifluoro-1-methyl-ethoxy)-benzoic acid (example 2.2). MS (m/e): MS (m/e): 462.0 (M+H+).

Sources & evidence

ORD record
ord-d679a3751d3f4dec8d453f0375873672
Source dataset
uspto-grants-2008_10
Patent number
US07442710B2

Reaction notes

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