4-Methyl-1,2,3,4-tetrahydroisoquinoline → (2-Isopropoxy-5-methanesulfonyl-phenyl)-(4-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

HRID 2117431Notes

Reaction equation

HRID 2117431 reaction equation
[CH3:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][NH:4][CH2:3]1.[CH:12]([O:15][C:16]1[CH:24]=[CH:23][C:22]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:21][C:17]=1[C:18](O)=[O:19])([CH3:14])[CH3:13]>>[CH:12]([O:15][C:16]1[CH:24]=[CH:23][C:22]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:21][C:17]=1[C:18]([N:4]1[CH2:3][CH:2]([CH3:1])[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5]1)=[O:19])([CH3:14])[CH3:13]

Participants

3

Reactant 2

HCID 137389344-Methyl-1,2,3,4-tetrahydroisoquinolineHCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acid

Product 1

HCID 58677900(2-Isopropoxy-5-methanesulfonyl-phenyl)-(4-methyl-3,4-dihydro-1H-isoquinolin-2-yl)-methanone

Procedure

Prepared in analogy to example 1.1 from 4-methyl-1,2,3,4-tetrahydro-isoquinoline (CA [110841-71-9]) and 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example 2.1).

Sources & evidence

ORD record
ord-4da1c864d4a54a8a8127c026cf985e64
Source dataset
uspto-grants-2008_10
Patent number
US07442710B2

Reaction notes

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