4-fluoro-1,2,3,4-tetrahydroisoquinoline → HCID 58677879, compound

HRID 2117445Notes

Reaction equation

HRID 2117445 reaction equation
[F:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][NH:4][CH2:3]1.[CH:12]([O:15][C:16]1[CH:24]=[CH:23][C:22]([S:25]([CH3:28])(=[O:27])=[O:26])=[CH:21][C:17]=1[C:18](O)=[O:19])([CH3:14])[CH3:13]>>[F:1][CH:2]1[C:11]2[C:6](=[CH:7][CH:8]=[CH:9][CH:10]=2)[CH2:5][N:4]([C:18]([C:17]2[CH:21]=[C:22]([S:25]([CH3:28])(=[O:27])=[O:26])[CH:23]=[CH:24][C:16]=2[O:15][CH:12]([CH3:14])[CH3:13])=[O:19])[CH2:3]1

Participants

3

Reactant 2

HCID 27747604-fluoro-1,2,3,4-tetrahydroisoquinolineHCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acid

Product 1

HCID 58677879HCID 58677879, compound

Procedure

Prepared in analogy to example 1.1 from 4-fluoro-1,2,3,4-tetrahydro-isoquinoline (CA [537033-79-7]) and 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example 2.1). MS (m/e): 392.0 (M+H+).

Sources & evidence

ORD record
ord-6c69b8cb9a0e4c7f83316d9613aeef53
Source dataset
uspto-grants-2008_10
Patent number
US07442710B2

Reaction notes

Loading…