6-Chloro-1,2,3,4-tetrahydroisoquinoline → (6-Chloro-3,4-dihydro-1H-isoquinolin-2-yl)-(2-cyclopropylmethoxy-5-methanesulfonyl-phenyl)-methanone

HRID 2117450Notes

Reaction equation

HRID 2117450 reaction equation
[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][NH:7][CH2:6][CH2:5]2.[CH:12]1([CH2:15][O:16][C:17]2[CH:25]=[CH:24][C:23]([S:26]([CH3:29])(=[O:28])=[O:27])=[CH:22][C:18]=2[C:19](O)=[O:20])[CH2:14][CH2:13]1>>[Cl:1][C:2]1[CH:3]=[C:4]2[C:9](=[CH:10][CH:11]=1)[CH2:8][N:7]([C:19]([C:18]1[CH:22]=[C:23]([S:26]([CH3:29])(=[O:28])=[O:27])[CH:24]=[CH:25][C:17]=1[O:16][CH2:15][CH:12]1[CH2:14][CH2:13]1)=[O:20])[CH2:6][CH2:5]2

Participants

3

Reactant 2

HCID 117895946-Chloro-1,2,3,4-tetrahydroisoquinolineHCID 211002282-Cyclopropylmethoxy-5-methanesulfonyl-benzoic acid

Product 1

HCID 58677875(6-Chloro-3,4-dihydro-1H-isoquinolin-2-yl)-(2-cyclopropylmethoxy-5-methanesulfonyl-phenyl)-methanone

Procedure

Prepared in analogy to example 1.1 from 6-chloro-1,2,3,4-tetrahydro-isoquinoline (CA [33537-99-4]) and 2-cyclopropylmethoxy-5-methanesulfonyl-benzoic acid (example 2.9). MS (m/e): 420.1 (M+H+).

Sources & evidence

ORD record
ord-d5327d38697e48b7a0a2dee2e55c14d3
Source dataset
uspto-grants-2008_10
Patent number
US07442710B2

Reaction notes

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