Quinoline, 1,2,3,4-tetrahydro-6-methoxy- → (2-Isopropoxy-5-methanesulfonyl-phenyl)-(6-methoxy-3,4-dihydro-2H-quinolin-1-yl)-methanone

HRID 2117451Notes

Reaction equation

HRID 2117451 reaction equation
[CH3:1][O:2][C:3]1[CH:4]=[C:5]2[C:10](=[CH:11][CH:12]=1)[NH:9][CH2:8][CH2:7][CH2:6]2.[CH:13]([O:16][C:17]1[CH:25]=[CH:24][C:23]([S:26]([CH3:29])(=[O:28])=[O:27])=[CH:22][C:18]=1[C:19](O)=[O:20])([CH3:15])[CH3:14]>>[CH:13]([O:16][C:17]1[CH:25]=[CH:24][C:23]([S:26]([CH3:29])(=[O:28])=[O:27])=[CH:22][C:18]=1[C:19]([N:9]1[C:10]2[C:5](=[CH:4][C:3]([O:2][CH3:1])=[CH:12][CH:11]=2)[CH2:6][CH2:7][CH2:8]1)=[O:20])([CH3:15])[CH3:14]

Participants

3

Reactant 2

HCID 67113Quinoline, 1,2,3,4-tetrahydro-6-methoxy-HCID 211002372-Isopropoxy-5-methylsulfonylbenzoic acid

Product 1

HCID 60209194(2-Isopropoxy-5-methanesulfonyl-phenyl)-(6-methoxy-3,4-dihydro-2H-quinolin-1-yl)-methanone

Procedure

Prepared in analogy to example 1.1 from 6-methoxy-1,2,3,4-tetrahydro-quinoline (CA [120-15-0]) and 2-isopropoxy-5-methanesulfonyl-benzoic acid (Example 2.1).

Sources & evidence

ORD record
ord-873d77135f6e4e298ff8ca2fee4ff65a
Source dataset
uspto-grants-2008_10
Patent number
US07442710B2

Reaction notes

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