4-(1,3-Thiazol-2-yl)benzaldehyde → 7-(4-Thiazol-2-yl-benzylamino)-heptanoic acid methyl ester

HRID 2117491Notes

Reaction equation

HRID 2117491 reaction equation
Cl.[CH3:2][O:3][C:4](=[O:12])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH2:11].[S:13]1[CH:17]=[CH:16][N:15]=[C:14]1[C:18]1[CH:25]=[CH:24][C:21]([CH:22]=O)=[CH:20][CH:19]=1>>[CH3:2][O:3][C:4](=[O:12])[CH2:5][CH2:6][CH2:7][CH2:8][CH2:9][CH2:10][NH:11][CH2:22][C:21]1[CH:20]=[CH:19][C:18]([C:14]2[S:13][CH:17]=[CH:16][N:15]=2)=[CH:25][CH:24]=1

Participants

3

Reactant 2

HCID 105356554-(1,3-Thiazol-2-yl)benzaldehydeHCID 13807349Methyl 7-aminoheptanoate hydrochloride

Product 1

HCID 542806757-(4-Thiazol-2-yl-benzylamino)-heptanoic acid methyl ester

Procedure

The title compound of Step A was prepared from 7-amino-heptanoic acid methyl ester hydrochloride, of Preparation 1, and 4-thiazol-2-yl-benzaldehyde, of Preparation 25, using the method described in Example 1, Step A. 1H NMR (400 MHz, CDCl3) δ7.91 (d, 2H), 7.84 (d, 1H), 7.38 (d, 2H), 7.30 (d, 1H), 3.82 (s, 2H), 3.65 (s, 3H), 2.62 (t, 2H), 2.29 (t, 2H), 1.61 (m, 2H), 1.51 (m, 2H), 1.33 (m, 4H); MS 333 (M+1).

Sources & evidence

ORD record
ord-4df6b38cd4aa4a199f59f89afb5026d6
Source dataset
uspto-grants-2008_10
Patent number
US07442702B2

Reaction notes

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