HCID 53870459, compound → HCID 18376206, compound

HRID 2117496Notes

Reaction equation

HRID 2117496 reaction equation
C[O:2][C:3]([C:5]1[S:6][C:7]([CH2:10][CH2:11][CH2:12][N:13]([CH2:20][CH2:21][CH2:22][C:23]2[CH:28]=[CH:27][CH:26]=[C:25]([Cl:29])[CH:24]=2)[S:14]([CH:17]2[CH2:19][CH2:18]2)(=[O:16])=[O:15])=[CH:8][CH:9]=1)=[O:4]>CCO>[Cl:29][C:25]1[CH:24]=[C:23]([CH2:22][CH2:21][CH2:20][N:13]([S:14]([CH:17]2[CH2:18][CH2:19]2)(=[O:15])=[O:16])[CH2:12][CH2:11][CH2:10][C:7]2[S:6][C:5]([C:3]([OH:4])=[O:2])=[CH:9][CH:8]=2)[CH:28]=[CH:27][CH:26]=1

Participants

3

Reactant 1

HCID 53870459HCID 53870459, compound

Product 1

HCID 18376206HCID 18376206, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

The title compound was prepared following the method described in Example 1, Step C from 5-(3-{[3-(3-chloro-phenyl)-propyl]-cyclopropanesulfonyl-amino}-propyl)-thiophene-2-carboxylic acid methyl ester of Step A except the reaction was performed in EtOH. 1H NMR (400 MHz, CDCl3) δ 7.62 (d, 1H, J=3.4 Hz), 7.42-7.00 (m, 4H), 6.62 (d, 1H, J=3.4 Hz), 3.25 (m, 2H), 2.92 (m, 2H), 2.31 (m, 1H), 2.20 (m, 2H), 1.32-0.90 (m, 4H); MS 440 (M−1).

Sources & evidence

ORD record
ord-23b5c6a43cc5424c99abde5bd73c6ce6
Source dataset
uspto-grants-2008_10
Patent number
US07442702B2

Reaction notes

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