Phosphate → HCID 18376061, compound

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Reaction Steps

A mixture of 7-[(4-imidazol-1-yl-benzyl)-(pyridine-2-sulfonyl)-amino]-heptanoic acid methyl ester (52 mg), porcine pancreas lipase (81 mg), acetone (1 mL), and phosphate buffer (pH=7, 5 mL) was stirred at room temperature for 20 h. The product was extracted into CH2Cl2 (3x). The organic solution was dried (MgSO4), filtered, and concentrated to provide the title compound (44 mg). 1H NMR (400 MHz, CD3OD) δ 8.71 (m, 1H), 8.24 (s, 1H), 8.07-7.98 (m, 2H), 7.64-7.54 (m, 6H), 7.19 (s, 1H), 4.57 (s, 2H), 3.29 (t, 2H), 2.15 (t, 2H), 1.41 (m, 2H), 1.33 (m, 2H), 1.13 (m, 4H).

Provenance & Evidence