Benzenesulfonyl chloride → HCID 53874300, compound

Participants

Reaction Steps

The title compound of Step B was prepared from {3-[(4-pyridin-4-yl-benzylamino)-methyl]-phenoxy}-acetic acid tert-butyl ester of Step A and benzenesulfonyl chloride following the method described in Example 3, Step B with a reaction time of 3 h. 1H NMR (400 MHz, CDCl3) δ 8.63 (d, 2H), 7.86 (dd, 2H), 7.62 -7.46 (m, 7H), 7.17 (d, 2H), 7.07 (t, 1H), 6.71 (dd, 1H), 6.60 (d, 1H), 6.54 (s, 1H), 4.35 (s, 2H), 4.32 (s, 2H), 4.29 (s, 2H), 1.46 (s, 9H); MS 545 (M+1). Step C: Ester Hydrolysis

Provenance & Evidence