Triethylamine → 4-(4-Ethylbenzenesulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone

Participants

Reaction Steps

In a similar manner to Step 1 of Example 233, 4-hydroxy-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0322 g, 0.0698 mmol) was dissolved in acetonitrile (0.650 mL), and the solution was treated with triethylamine (0.0580 mL, 0.419 mmol) and 4-ethylbenzene-1-sulfonyl chloride (0.0430 g, 0.209 mmol) to obtain 4-(4-ethylbenzenesulfonyloxy)-7-[1-(tert-butoxycarbonyl)-5-(piperidinomethyl)indol-2-yl]isoindolinone (0.0224 g, yield 51%).

Provenance & Evidence