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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 2117628Generated: October 30, 2026

Sodium Azide → 1-(2-Azidoethyl)-4-(4-nitrophenyl)piperazine

https://huagongshe.com/reaction/2117628

Reaction equation

Participants

RoleNameHCIDCharge
ReactantSodium AzideHCID 33557—
ReactantDiisopropylethylamineHCID 81531—
Reactant1-(2-Chloroethyl)-4-(4-nitrophenyl)piperazineHCID 11771183—
SolventDimethyl SulfoxideHCID 679—
SolventEthyl AcetateHCID 8857—
Product1-(2-Azidoethyl)-4-(4-nitrophenyl)piperazineHCID 86024166—

Reaction Conditions

Temperature80 °C

Reaction Steps

1-(2-Chloroethyl)-4-(4-nitrophenyl)piperazine (1 g, 0.0033 mol) was dissolved in dimethylsulphoxide (30 mL) and sodium azide (0.34 g, 0.0052 mol) was added followed by Hunig's base (0.84 g, 0.0065 mol). The mixture was stirred at 80° C. overnight in a sealed tube, then diluted with ethyl acetate and washed with water, dried and evaporated to yield the title compound. LCMS: 90%, t=0.85 min, [MH+]=277.26.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS07442698B2
Source datasetuspto-grants-2008_10
ORD IDord-b23d9e8950b4403699044216f093cfb8
Source noteuspto-grants-2008_10