HCID 3522175, compound → 2-(4-Aminophenyl)-1-(4-methylpiperazin-1-yl)ethan-1-one

Participants

Reaction Steps

A solution of 1-methyl-4-[(4-nitrophenyl)acetyl]piperazine(1.5 g, 5.70 mmol) in ethanol (30 mL) was reduced over palladium/charcoal (10% wt, 50% wet, 150 mg) with hydrogen under atmospheric pressure and room temperature for 18 h. The catalyst was separated by filtration through celite and the solvent evaporated to the title compound as a brown oil. 1H NMR: (400 MHz, CDCl3); 2.21 (2H, t, J 5.01), 2.24 (3H, s), 2.34(2H, t, J 5.13), 3.45 (2H, t, J 5.13), 3.61 (2H, s), 3.63-3.66 (2H, m), 6.64 (2H, d, J 8.56), 7.01 (2H, d, J 8.31).

Provenance & Evidence