3-Pyridinemethanol → HCID 69204374, compound

HRID 2117645Notes

Reaction equation

HRID 2117645 reaction equation
[CH3:1][O:2][C:3]1[CH:8]=[CH:7][C:6]([N:9]=[C:10]=[O:11])=[CH:5][CH:4]=1.[N:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][OH:19])[CH:13]=1>C1(C)C=CC=CC=1>[N:12]1[CH:17]=[CH:16][CH:15]=[C:14]([CH2:18][O:19][C:10](=[O:11])[NH:9][C:6]2[CH:5]=[CH:4][C:3]([O:2][CH3:1])=[CH:8][CH:7]=2)[CH:13]=1

Participants

4

Reactant 2

HCID 75103-PyridinemethanolHCID 794431-Isocyanato-4-methoxybenzene

Product 1

HCID 69204374HCID 69204374, compound

Reagents, catalysts & solvents 1

HCID 1140TolueneSolvent

Conditions

Temperature
100 °C

Procedure

A resealable tube was charged with 4-methoxyphenylisocyanate (1.00 g, 6.70 mmol), 3-pyridylcarbinol (0.800 g, 7.33 mmol), and toluene (4 mL). The tube was sealed and the mixture was heated at 100° C. for 20 h. The reaction mixture was cooled to room temperature. The resulting white solid was collected by suction filtration and washed with diethyl ether. The solid was dried under vacuum to give (4-methoxyphenyl)-carbamic acid pyridin-3-ylmethyl ester a white solid.

Workup

  1. customThe tube was sealed
  2. temperatureThe reaction mixture was cooled to room temperature
  3. filtrationThe resulting white solid was collected by suction filtration
  4. washwashed with diethyl ether
  5. customThe solid was dried under vacuum

Sources & evidence

ORD record
ord-b0c5985d4da6425d9bd3e8646283a8ee
Source dataset
uspto-grants-2008_10
Patent number
US07442698B2

Reaction notes

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