反应详情

2-(4-Fluorophenyl)-1-pyridin-4-ylethanone (0.04 mol/8.6 g) (prepared as described in example 20, steps (a) and (b)) was dissolved in 80 ml of glacial acetic acid. NaNO2 (0.04 mol/2.76 g), dissolved in the smallest amount of H2O possible, was then added dropwise with ice-cooling and stirring. The mixture was then stirred at 0° C. for another 2 h. 500 ml of H2O were then added, and the mixture was stirred at room temperature for another 1 h. The title compound precipitated as a white powder. The precipitate was filtered off, washed with H2O and dried over P2O5 under reduced pressure. Yield: 5.9 g (60%)

1. additionwas then added dropwise with ice-
2. temperaturecooling
3. stirringThe mixture was then stirred at 0° C. for another 2 h
4. stirringthe mixture was stirred at room temperature for another 1 h
5. customThe title compound precipitated as a white powder
6. filtrationThe precipitate was filtered off
7. washwashed with H2O
8. dry with materialdried over P2O5 under reduced pressure