Carbon Dioxide → HCID 69312753, compound

Participants

Reaction Steps

2-[4-(4-Fluorophenyl)-1-methyl-5-pyridin-4-yl-1H-imidazol-2-ylsulfanyl]acetic acid (1 mmol/0.344 g) are dissolved in 100 ml of absolute THF, carbonyldiimidazole (1 mmol/0.162 g) is added and the mixture is stirred at room temperature until the evolution of carbon dioxide has ceased. Histidine (1 mmol) is then added, and the mixture is heated under reflux for 2 h. The mixture is then poured into 400 ml of 1 N Na2CO3 solution and concentrated in a rotary evaporator. The residue is extracted 3 times with in each case 150 ml of dichloromethane/ethanol 1:1, dried over sodium sulfate and concentrated in a rotary evaporator. The residue is dissolved in a little acetone and re-precipitated using diethyl ether. The precipitate formed is filtered off with suction and dried over P2O5.

Provenance & Evidence