HCID 69312069, compound → HCID 67037521, compound

Participants

Reaction Steps

1-Isopropyl-2-methoxymethyl-5-acetylimidazole (Method 12; 3.34 g, 17 mmol) was dissolved in a mixture of DMF (34 ml) and DMF.DEA (11.5 ml, 68 mmol) and the mixture heated under reflux, under an atmosphere of nitrogen, for 18 hours. The volatiles were removed by evaporation. A solid was precipitated with ether, collected by filtration and air dried to yield the title compound as a brown solid (2.25 g, 53%); NMR 1.43 (d, 6H), 2.95 (m, 6H), 3.20 (s, 3H), 4.46 (s, 2H), 5.00 (m, 1H), 5.56 (d, 1H), 7.55 (m, 2H); m/z 252.

Provenance & Evidence