2-Bromopyridine → 2-(3-Bromophenyl)pyridine

Participants

Reaction Conditions

Reaction Steps

A mixture of 2-bromopyridine (2.5 g, 15.8 mmol), 3-bromophenol (5.5 g, 31.6 mmol) and potassium carbonate (2.2 g, 15.8 mmol) was stirred at 200° C. for 3 hours. After the reaction mixture was allowed to cool, to which was then added an aqueous 1 mol/L sodium hydroxide solution, the mixture was extracted with dichloromethane, the solvent was distilled off, and the residue was purified by silica gel column chromatography and recrystallization, thereby obtaining 2.9 g of desired compound as white crystal.

Provenance & Evidence