2-(Dimethylamino)ethanol → HCID 178506692, compound

Participants

Reaction Conditions

Reaction Steps

A hexane (70 ml) solution of N,N-dimethylaminoethanol (12.0 ml, 118.5 mmol) was dropwise added to a hexane solution of n-butyllithium (150 ml, 1.58 M, 237.0 mmol) at 5° C. while 30 minutes. Next, a hexane (10 ml) solution of 2-phenylpyridine (8.5 ml, 59.3 mmol) was dropwise added to the mixture at 5° C. while 20 minutes. A hexane solution of 2-lithio-6-phenylpyridine was prepared by the mixture stirred at 5° C. for 1 hour additionally.

Provenance & Evidence