Hydrochloric Acid → HCID 135556085, compound

Participants

Reaction Conditions

Reaction Steps

Hydrochloric acid (14.8 ml, 177.2 mmol) was added to pyridine (14.3 ml, 177.2 mmol), and the mixture was heated with removing water till an internal reaction temperature reach to 180° C. After the reaction mixture was cooled to 120° C., 6-(2-methoxyphenyl)-6′-phenyl-2,2′-bipyridine (3.0 g, 8.9 mmol) obtained by Example 13 was added to the reaction mixture and stirred for at 180° C. for 2 hours. After the reaction mixture was cooled, to which was then added an aqueous 1 mol/L sodium hydroxide solution, the mixture was extracted with dichloromethane, the solvent was distilled off, and the residue was purified by silica gel column chromatography and recrystallization, thereby obtaining 2.7 g of 2-(6′-phenyl-2,2′-bipyridine-6-yl)phenol as yellow crystal. Yield: 93.9%.

Provenance & Evidence