Acetic Anhydride → HCID 23135820, compound

HRID 2117815Notes

Reaction equation

HRID 2117815 reaction equation
[C:1](OC(=O)C)(=[O:3])[CH3:2].[C:8]1([C:14]2[N:19]=[C:18]([C:20]3[CH:25]=[CH:24][CH:23]=[C:22]([C:26]4[CH:31]=[CH:30][CH:29]=[CH:28][C:27]=4[OH:32])[N:21]=3)[CH:17]=[CH:16][CH:15]=2)[CH:13]=[CH:12][CH:11]=[CH:10][CH:9]=1>N1C=CC=CC=1>[C:1]([O:32][C:27]1[CH:28]=[CH:29][CH:30]=[CH:31][C:26]=1[C:22]1[N:21]=[C:20]([C:18]2[CH:17]=[CH:16][CH:15]=[C:14]([C:8]3[CH:9]=[CH:10][CH:11]=[CH:12][CH:13]=3)[N:19]=2)[CH:25]=[CH:24][CH:23]=1)(=[O:3])[CH3:2]

Participants

4

Reactant 2

HCID 7918Acetic AnhydrideHCID 135556085HCID 135556085, compound

Product 1

HCID 23135820HCID 23135820, compoundYield 93%

Reagents, catalysts & solvents 1

HCID 1049PyridineSolvent

Procedure

Acetic anhydride (580 μL, 6.2 mmol) was dropwise added to a pyridine (20 ml) solution of 2-(6′-phenyl-2,2′-bipyridine-6-yl)phenol (1.0 g, 3.1 mmol) obtained by Example 14, then the mixture was stirred for 24 hours at room temperature. The solvent was distilled off from the reaction mixture, and the residue was purified by silica gel column chromatography and recrystallization, thereby obtaining 1.05 g of 6-(2-acetoxyphenyl)-6′-phenyl-2,2′-bipyridine as yellow crystal. Yield: 93.0%.

Workup

  1. distillationThe solvent was distilled off from the reaction mixture
  2. customthe residue was purified by silica gel column chromatography and recrystallization

Sources & evidence

ORD record
ord-4959315a901147958df9c329e2ac38b2
Source dataset
uspto-grants-2008_10
Patent number
US07442797B2

Reaction notes

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