766508-80-9 → HCID 18790614, compound

HRID 2117860Notes

Reaction equation

HRID 2117860 reaction equation
[NH2:1][C:2]1[S:3][CH:4]=[C:5]([C:7]2[CH:12]=[CH:11][C:10]([CH2:13][CH2:14][NH:15]C(=O)C)=[CH:9][CH:8]=2)[N:6]=1>C(O)C>[NH2:15][CH2:14][CH2:13][C:10]1[CH:9]=[CH:8][C:7]([C:5]2[N:6]=[C:2]([NH2:1])[S:3][CH:4]=2)=[CH:12][CH:11]=1

Participants

3

Reactant 1

HCID 2474355766508-80-9

Product 1

HCID 18790614HCID 18790614, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

N-{2-[4-(2-Amino-1,3-thiazol-4-yl)phenyl]ethyl}acetamide (0.6 g) was dissolved in ethanol (10 mL) and hydrochloric acid concentrate (10 mL). The mixture was refluxed for 5 hours. The solvent was evaporated in vacuo. The residue was washed with ethyl ether to give 4-[4-(2-aminoethyl)phenyl]-1,3-thiazol-2-amine dihydrochrolide (0.5 g, 84.6%).

Workup

  1. concentrationhydrochloric acid concentrate (10 mL)
  2. temperatureThe mixture was refluxed for 5 hours
  3. customThe solvent was evaporated in vacuo
  4. washThe residue was washed with ethyl ether

Sources & evidence

ORD record
ord-dba932fc03be46bf967cc537107c043d
Source dataset
uspto-grants-2008_10
Patent number
US07442715B2

Reaction notes

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