反应详情

Ethyl 3-bromo-4-(4-iodophenyl)-2-oxobutanoate (1.32 g) was dissolved in ethanol (26 ml), and then, thiourea (244 mg) was added to the solution. The reaction mixture was refluxed for 1 h under nitrogen atmosphere. The cooled reaction mixture was evaporated in vacuo. The crude material was triturated with diethyl ether to give ethyl 2-amino-5-(4-iodobenzyl)-1,3-thiazole-4-carboxylate hydrobromide as a pale yellow solid.

1. temperatureThe reaction mixture was refluxed for 1 h under nitrogen atmosphere
2. customThe cooled reaction mixture
3. customwas evaporated in vacuo
4. customThe crude material was triturated with diethyl ether