Dimethylformamide → HCID 12192481, compound

Participants

Reaction Steps

A mixture of furopyrrole 6 (1.5 g, 4.08 mmol), methyl tosylate (1.14 g, 6.12 mmol), potassium carbonate (1.13 g, 8.16 mmol) and dimethylformamide was stirred at room temperature overnight. Water was then added, and the organic component extracted with DCM. The solvent was removed, and washing with water then methanol gave the methylated compound 7 as a red solid (0.831 g, 53%), m.p. 215-216° C. δH (CDCl3) 8.19 and 7.61 (each 2H, AA′BB′, p-C6H4Br), 7.78-7.73 (2H, m, o-Ph), 7.54-7.50 (3H, m, m/p-Ph) and 3.38 (3H, s, NCH3). λmax (abs) (DCM)/nm 454 (ε 15,878)

Provenance & Evidence