HCID 86614874, compound → HCID 86614881, compound

HRID 2117998Notes

Reaction equation

HRID 2117998 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]3[C:17](=[CH:18][CH:19]=2)[CH:16]=[CH:15][C:14]2[CH:13]=[CH:12][C:11]([CH2:20][C:21]([CH3:23])=[O:22])=[CH:10][C:9]3=2)[CH2:3][CH2:2]1.Cl[C:25]1C=C2C(=CC=1)C1N(COCC[Si](C)(C)C)C(C3C(C#N)=CC=CC=3C#N)=NC=1C1C=CC(CC(=O)C)=CC2=1>>[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]3[C:17](=[CH:18][CH:19]=2)[CH:16]=[CH:15][C:14]2[CH:13]=[CH:12][C:11]([CH2:20][C:21]([CH3:25])([OH:22])[CH3:23])=[CH:10][C:9]3=2)[CH2:2][CH2:3]1

Participants

3

Reactant 2

HCID 86614874HCID 86614874, compoundHCID 86614879HCID 86614879, compound

Product 1

HCID 86614881HCID 86614881, compound

Procedure

This phenanthrene was prepared as described in Step 3 of Example 135, substituting 1-[6-(cyclopropylmethoxy)-3-phenanthryl]acetone from Step 3 above for 2-(9-chloro-6-(2-oxopropyl)-1-{[2-(trimethylsilyl)ethoxy]methyl)-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile. The crude product was used directly in the next reaction.

Sources & evidence

ORD record
ord-d23f0451df3f4bc9ba1969176f2d6867
Source dataset
uspto-grants-2008_10
Patent number
US07442716B2

Reaction notes

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