HCID 86614874, compound → HCID 86614884, compound

HRID 2118001Notes

Reaction equation

HRID 2118001 reaction equation
[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]3[C:38](=[CH:39][CH:40]=2)[C:16]2[N:17]([CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:37])([CH3:36])[CH3:35])[C:18]([C:20]4[C:27]([C:28]#[N:29])=[CH:26][CH:25]=[CH:24][C:21]=4[C:22]#[N:23])=[N:19][C:15]=2[C:14]2[CH:13]=[CH:12][C:11]([CH2:41][C:42](=[O:44])[CH3:43])=[CH:10][C:9]3=2)[CH2:3][CH2:2]1.Cl[C:46]1C=C2C(=CC=1)C1N(COCC[Si](C)(C)C)C(C3C(C#N)=CC=CC=3C#N)=NC=1C1C=CC(CC(=O)C)=CC2=1>>[CH:1]1([CH2:4][O:5][C:6]2[CH:7]=[C:8]3[C:38](=[CH:39][CH:40]=2)[C:16]2[N:17]([CH2:30][O:31][CH2:32][CH2:33][Si:34]([CH3:35])([CH3:37])[CH3:36])[C:18]([C:20]4[C:27]([C:28]#[N:29])=[CH:26][CH:25]=[CH:24][C:21]=4[C:22]#[N:23])=[N:19][C:15]=2[C:14]2[CH:13]=[CH:12][C:11]([CH2:41][C:42]([OH:44])([CH3:46])[CH3:43])=[CH:10][C:9]3=2)[CH2:3][CH2:2]1

Participants

3

Reactant 2

HCID 86614874HCID 86614874, compoundHCID 87287619HCID 87287619, compound

Product 1

HCID 86614884HCID 86614884, compound

Procedure

This imidazole was prepared as described in Step 3, Example 135, substituting 2-(9-(cyclopropylmethoxy)-6-(2-oxopropyl)-1-{[2-(trimethylsilyl)ethoxy]methyl}-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile from Step 5 above for of 2-(9-chloro-6-(2-oxopropyl)-1-{[2-(trimethylsilyl)ethoxy]methyl)-1H-phenanthro[9,10-d]imidazol-2-yl)isophthalonitrile.

Sources & evidence

ORD record
ord-b843894aaf1a4a7094d2f2c32d5f1eaa
Source dataset
uspto-grants-2008_10
Patent number
US07442716B2

Reaction notes

Loading…