HCID 178440597, compound → HCID 178458986, compound

HRID 2118005Notes

Reaction equation

HRID 2118005 reaction equation
[Si]([O:8][C:9]([CH3:44])([CH3:43])[CH2:10][C:11]1[CH:12]=[CH:13][C:14]2[C:27]3[N:26]=[C:25]([C:28]4[C:33]([Br:34])=[CH:32][C:31]([F:35])=[CH:30][C:29]=4[Br:36])[NH:24][C:23]=3[C:22]3[C:17](=[CH:18][C:19]([O:37][CH2:38][CH2:39][CH:40]4[CH2:42][CH2:41]4)=[CH:20][CH:21]=3)[C:15]=2[CH:16]=1)(C(C)(C)C)(C)C.[Si](OC(C)(C)CC1C=CC2C3N=C(C4C(Br)=CC=CC=4Br)NC=3C3C(=CC(OCC4CC4)=CC=3)C=2C=1)(C(C)(C)C)(C)C>>[CH:40]1([CH2:39][CH2:38][O:37][C:19]2[CH:18]=[C:17]3[C:22](=[CH:21][CH:20]=2)[C:23]2[NH:24][C:25]([C:28]4[C:29]([Br:36])=[CH:30][C:31]([F:35])=[CH:32][C:33]=4[Br:34])=[N:26][C:27]=2[C:14]2[CH:13]=[CH:12][C:11]([CH2:10][C:9]([CH3:44])([OH:8])[CH3:43])=[CH:16][C:15]3=2)[CH2:42][CH2:41]1

Participants

3

Reactant 2

HCID 178440597HCID 178440597, compoundHCID 178440598HCID 178440598, compound

Product 1

HCID 178458986HCID 178458986, compound

Procedure

This imidazole was prepared as described in Step 8 of Route A of Example 168, substituting 6-(2-{[tert-butyl(dimethyl)silyl]oxy}-2-methylpropyl)-9-(2-cyclopropylethoxy)-2-(2,6-dibromo-4-fluorophenyl)-1H-phenanthro[9,10-d]imidazole from Step 5 above for 6-(2-{[tert-butyl(dimethyl)silyl]oxy}-2-methylpropyl)-9-(cyclopropylmethoxy)-2-(2,6-dibromophenyl)-1H-phenanthro[9,10-d]imidazole.

Sources & evidence

ORD record
ord-daafeae973354d48b0101d3abf3b7d10
Source dataset
uspto-grants-2008_10
Patent number
US07442716B2

Reaction notes

Loading…