Pivaloyl chloride → HCID 21925550, compound

HRID 2118037Notes

Reaction equation

[CH3:1][C:2]([CH3:7])([CH3:6])[C:3](Cl)=[O:4].[Cl:8][C:9]1[CH:34]=[CH:33][C:12]2[N:13]3[C:17]([CH2:18][NH:19][CH2:20][C:11]=2[CH:10]=1)=[N:16][N:15]=[C:14]3[CH:21]1[CH2:26][CH2:25][N:24]([C:27]2[N:32]=[CH:31][CH:30]=[CH:29][N:28]=2)[CH2:23][CH2:22]1>>[Cl:8][C:9]1[CH:34]=[CH:33][C:12]2[N:13]3[C:17]([CH2:18][N:19]([C:3](=[O:4])[C:2]([CH3:7])([CH3:6])[CH3:1])[CH2:20][C:11]=2[CH:10]=1)=[N:16][N:15]=[C:14]3[CH:21]1[CH2:26][CH2:25][N:24]([C:27]2[N:28]=[CH:29][CH:30]=[CH:31][N:32]=2)[CH2:23][CH2:22]1

Participants

Reactant 2

HCID 62493Pivaloyl chloride

HCID 21925629HCID 21925629, compound

Product 1

HCID 21925550HCID 21925550, compoundYield 42%

Procedure

The title compound was prepared from 2,2-Dimethyl-propionyl chloride and the amine of example 12, in 42% yield, using the procedure described in example 3.

Sources & evidence

ORD record: ord-cb0ffdbd4840482d8572a0ad6fa7c2df
Source dataset: uspto-grants-2008_10
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US07442795B2

Reaction notes

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