Triethylamine → HCID 10074452, compound

Participants

Role	Name	HCID	Charge
Reactant	Triethylamine	HCID 8471	—
Reactant	4-Morpholinecarbonyl chloride	HCID 84810	—
Reactant	8-Chloro-1-(3,4,5,6-tetrahydro-2h-[1,2']bipyridinyl-4-yl)-5,6-dihydro4h-2,3,5,10b-tetraaza-benzo[e]azulene	HCID 11326488	—
Solvent	Dichloromethane	HCID 6344	—
Product	Ammonia	HCID 222	—
Product	HCID 10074452	HCID 10074452	125.3%

Reaction Steps

A mixture of the amine from example 4 (150 mg, 0.42 mmol), morpholinecarbonyl chloride (0.15 ml, 1.26 mmol) and triethylamine (0.18 ml, 1.26 mmol) in dichloromethane (10 ml) was stirred at room temperature for 18 hours. The reaction mixture was evaporated under reduced pressure and the residue purified by column chromatography on silica gel using dichloromethane:methanol:0.88 ammonia (95:5:0.5), to afford the title compound as a white solid (130 mg).

Provenance & Evidence

DOI	10.6084/m9.figshare.5104873.v1
Patent number	US07442795B2
Source dataset	uspto-grants-2008_10
ORD ID	ord-5f24c4389dd045fe88735a5a168f1b12
Source note	uspto-grants-2008_10