HuagongsheHuagongshe Chemistry Print Report · For research reference only
Triethylamine → 5-amino-1(2H)-phthalazinone
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Triethylamine | HCID 8471 | — |
| Reactant | 5-Nitrophthalazin-1(2H)-one | HCID 20323190 | — |
| Reactant | HCID 178418361 | HCID 178418361 | — |
| Catalyst | Palladium | HCID 23938 | — |
| Solvent | Ethyl Acetate | HCID 8857 | — |
| Product | 5-amino-1(2H)-phthalazinone | HCID 12341002 | 100.5% |
Reaction Steps
980 mg of 5-nitro-phthalazin-1-one (Example 66) and 100 mg of palladium on activated carbon are suspended in 50 ml of ethyl acetate and 1 ml of triethylamine and hydrogenated with hydrogen under normal pressure. It is filtered through diatomaceous earth, and the solvent is removed in a vacuum. As a crude product, 830 mg of 5-amino-phthalazin-1-one is obtained as a solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07442794B2 |
| Source dataset | uspto-grants-2008_10 |
| ORD ID | ord-f8389fed74364c499b33901c0463bd13 |
| Source note | uspto-grants-2008_10 |