Trifluoroacetic acid → HCID 11454316, compound

Participants

Reaction Conditions

Reaction Steps

Compound 19 was dissolved in CH2Cl2 (10 mL) and cooled to 0° C. in an ice bath. TFA (5 mL, 65 mmol) was and the mixture stirred in an ice bath for 2 h. The reaction was concentrated at RT and dried under high vacuum to provide the title compound, 18, as a white solid (53 mg, 74%). 1HNMR (400 MHz, DMSO-d6): δ 0.86 (t, 3H), 2.40 (q, 2H), 6.51 (d, J=16 Hz, 1H), 6.90 (d, J=8 Hz, 2H), 6.96 (d, J=8 Hz, 2H), 7.14-7.18 (m, 3H), 7.16-7.20 (m, 4H), 7.54 (d, J=8 Hz, 2H), 7.56 (d, J=16 Hz, 1H), 7.66-7.71 (m, 3H), 8.03 (d, J=8 Hz, 2H), 12.2 (br s, 1H); MS, m/z, 473 (M−H)−.

Provenance & Evidence